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Free Radical Biology and Medicine 62, 1325

The first tesamorelin human trials (Phase 1) began in the early 2000s, with Phase 3 trial dates spanning 2005-2008 (Study LIPO-010 Phase 3 completed 2008), leading to the November 2010 approval

Delivery Systems and Routes of Administration Injectable Formulations Most approved peptide therapeutics are administered by injection due to their poor oral bioavailability

doi: 10.1073/pnas.1705233114 75 LengP.YuanB.GuoY

15 Neutralization of the rat homolog of human CXCL5 and CXCL6 in an IRI model resulted in reduced neutrophil sequestration in the liver and serum ALT levels